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Indication & Dosage |
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| Oral |
| LONG-TERM MANAGEMENT OF ANGINA |
| Adult:
20-120 mg daily in divided doses. Gradually increase according to patient's response. |
| Max Dosage: 240 mg daily. |
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| Oral |
| MANAGEMENT OF HEART FAILURE |
| Adult:
30-160 mg daily in divided doses. |
| Max Dosage: 240 mg daily. |
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| Intravenous |
| MANAGEMENT OF UNSTABLE ANGINA |
| Adult:
2-12 mg/hr titrated according to patient's response. |
| Max Dosage: 20 mg/hr. |
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| Intravenous |
| MANAGEMENT OF HEART FAILURE |
| Adult:
2-12 mg/hr titrated according to patient's response. |
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| Intracoronary |
| PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY |
| Adult:
1 mg as a bolus before balloon inflation. |
| Max Dosage: within a 30-min period: 5 mg. |
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| Sublingual |
| MANAGEMENT OF HEART FAILURE |
| Adult:
5-15 mg every 2-3 hr. |
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| Sublingual |
| MANAGEMENT OF ACUTE ANGINA |
| Adult:
2-12 mg/hr titrated according to patient's response |
| Max Dosage: 240 mg daily. |
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| Administration |
Should be taken on an empty stomach (i.e. At least one hour before food or four hours after food). (Take on an empty stomach 1/2 hr before meals.) |
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| Precautions |
Raised intracranial pressure, hypotension, hypovolaemia. Mitral valve prolapse, arterial hypoxaemia, glaucoma, elderly, hypothyroidism, malnutrition, pregnancy, lactation. |
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Potentially Life-threatening
Adverse Drug Reactions |
Hypotension, tachycardia, flushing, headache, dizziness, palpitation, syncope, confusion. Nausea, vomiting, abdominal pain. Apprehension, restlessness, weakness and vertigo. |
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| Adverse Drug Reactions |
Severe hypotension, circulatory collapse. |
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| Interactions |
Increased hypotensive effects with alcohol or vasodilators. Marked orthostatic hypotension may occur when used with calcium channel blockers. Vasodilatory effect may be reduced with dihydroergotamine. Ergotamine effects may be enhanced. Reduced effectiveness of sublingual form with disopyramide. |
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